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Targeting oxygen free-radicals in diabetic wound healing: three case reports

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Targeting oxygen free-radicals in diabetic wound healing: three case reports

Ahmed Ramadan Wahdan, Mohamed Abouzeid Ahmed Gaballa Ali, Nafad Mohammad Elhadidi
17 January 2022

The Arabian Gulf region has seen an increasing rise in diabetic foot ulcers (DFUs) with prevalence ranging from 4.7% to 19% in Saudi Arabia (Hu et al, 2014; Mairghani et al, 2017). Current practices for standard of care include wound debridement, wound offloading and dressings. The authors successfully managed diabetic foot ulcers with oxygen free-radical binding technology as an adjuvant therapy for our patients. HemaGel® (VH Pharma), a hydrophilic gel, contains sterically hindered amines that bind with reactive oxygen species (ROS) and thereby accelerates wound healing by showing an anti-inflammatory effect. The three case reports in this article discuss the use of targeted oxygen free radicals to promote wound healing by oxidant/antioxidant disequilibrium methodology in the authors’ patients. With supporting diabetes controlling medications and HemaGel, wound healing was achieved successfully in these patients.

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